Purpose: To report a case of Candida glabrata endophthalmitis after deep anterior lamellar keratoplasty

Methods: Interventional case report

Results: A young male patient presented with asymptomatic white to cream-colored interface deposits two months after deep anterior lamellar keratoplasty. After a while, severe anterior chamber reaction together with decreased visual acuity developed. Because of the progression of the lesions, irrigation of the interface was considered and finally, penetrating keratoplasty was performed due to a rupture in the Descemet’s membrane. The microbiological evaluation of the irrigation fluid demonstrated Candida glabrata. After regrafting, scattered endothelial plaques together with hypopyon formation and anterior vitreous inflammation developed, that improved with intensive antifungal therapy. The patient remained asymptomatic with a clear graft in the 6-month follow up.

Conclusion: Yeast-induced keratitis may rarely occur after corneal transplantation and it should be considered and treated aggressively in all cases of interface deposits due to fungi after lamellar corneal graft.